Find a Doctor View in PubMed, Introduction to the reports from the National Cancer Institute First International Workshop on the Biology, Prevention, and Treatment of Relapse after Allogeneic Hematopoietic Stem Cell Transplantation Biol Blood Marrow Transplant. View in PubMed, Proceedings from the National Cancer Institute's Second International Workshop on the Biology, Prevention, and Treatment of Relapse after Hematopoietic Stem Cell Transplantation: part IIAutologous Transplantation-novel agents and immunomodulatory strategies. View in PubMed, Feasibility of treating post-transplantation minimal residual disease in children with acute leukemia Biol Blood Marrow Transplant. I also oversee our education programs that includes students at stages of training ranging from high school to post-doctoral.” “I offer my unreserved recommendation for his application” Alan S. … Virtual Event To ensure Zoom meeting security, all participants are required to register once for this series. 2011 Apr; 17(4):443-54. . 2017 Sep 10; 9(9). . Biol Blood Marrow Transplant. Alan S. Wayne, MD Director, Children’s Center for Cancer and Blood Diseases, Children’s Hospital Los Angeles Head, Division of Hematology, Oncology and Blood and Marrow Transplantation at the Keck School of Medicine of the University of Southern California (USC) View in PubMed, Improving access to novel agents for childhood leukemia Cancer. advancement. Getting Here CHLA is the only approved center in Southern California, having played a pivotal role in the two multicenter trials leading to approval. View in PubMed, Hematopoietic stem cell donation in children: a review of the sibling donor experience J Psychosoc Oncol. 2016. leukemia in a generation—and Children’s Hospital Los Angeles has played a major role in its . Search for more papers by this author The Therapeutic Advances in Childhood Leukemia & Lymphoma (TACL) consortium is comprised of a group of children’s hospitals and universities that work closely together to rapidly develop and carry out clinical trials. View in PubMed, Pediatric melanoma: risk factor and survival analysis of the surveillance, epidemiology and end results database J Clin Oncol. Alan Wayne, MD, and Michael Pulsipher, MD, helped . 2012 Nov 01; 30(31):3876-83. . He graduated from … 2008 Mar; 17(3):304-7. . 2010 Mar 15; 16(6):1894-903. . Children's Hospital Los Angeles [Recruiting] Los Angeles, California, United States, 90027 Contact: Alan Wayne, MD awayne@chla.usc.edu Contact: Karen Reed kreed@chla.usc.edu: Children's Hospital of Orange County [Recruiting] Orange, California, United States, 92868 Contact: Leonard Sender, MD lsender@uci.edu Contact: Laura Gates, RN lgates@choc.org 2015 Jan; 50(1):15-9.. View in PubMed, New frontiers in pediatric Allo-SCT: novel approaches for children and adolescents with ALL Bone Marrow Transplant. Get … Dr. Alan Wayne, CHLA speaks on stage during The T.J. Martell Foundation 43rd New York Honors Gala at Cipriani 42nd Street on October 15, 2018 in New York City. 2013 Nov; 19(11):1537-45. . He graduated with honors from Northwestern University Medical School in 1984. Dear friends and family, After couple of years of participating in the biking portion of the Nautica Malibu Triathlon, I decided to run the classic distance course this year (1/2 mile swim, 17 miles bike, 4 mile run; which is making Mushi very nervous ☺). View in PubMed, Results from an international phase 2 study of the anti-CD22 immunotoxin moxetumomab pasudotox in relapsed or refractory childhood B-lineage acute lymphoblastic leukemia Pediatr Blood Cancer. 1995 Dec 29; 770:376-7. . 2013 Dec; 19(12):1661-9. . 2016 07; 38(5):345-9. . 2017 Sep - Oct; 34(6-7):355-364. . Give Us Feedback, Children's Center for Cancer and Blood Diseases, Five Things Parents Need to Know About CAR T-Cell Therapy for Cancer, Trained T-Cells to Target Toxic Viruses in Pediatric Patients, First Randomized Trial to Determine Most Effective, Least Toxic Treatment for Babies with Severe Combined Immunodeficiency, 4650 Sunset Blvd. 2006 Aug; 160(8):818-22. . . 1993 Jan; 11(1):84-90. . History. . View in PubMed, Induction of Immune Response after Allogeneic Wilms' Tumor 1 Dendritic Cell Vaccination and Donor Lymphocyte Infusion in Patients with Hematologic Malignancies and Post-Transplantation Relapse Biol Blood Marrow Transplant. View in PubMed, Cytotoxicity of the anti-CD22 immunotoxin HA22 (CAT-8015) against paediatric acute lymphoblastic leukaemia Br J Haematol. View in PubMed, Restricted cell surface expression of receptor tyrosine kinase ROR1 in pediatric B-lineage acute lymphoblastic leukemia suggests targetability with therapeutic monoclonal antibodies PLoS One. 2013 Feb 14; 121(7):1165-74. . View in PubMed, Enhancing immunotoxin cell-killing activity via combination therapy with ABT-737 Leuk Lymphoma. Biol Blood Marrow Transplant. View in PubMed, Methylation of the DPH1 promoter causes immunotoxin resistance in acute lymphoblastic leukemia cell line KOPN-8 Leuk Res. Kymriah (tisagenlecleucel) is a FDA-approved CD19+ targeted Chimeric Antigen Receptor (CAR) T-cell therapy. 1993 Jan; 28(1):72-5. . 2003 Oct; 17(5):1243-60. . 1996 May; 2(2):100-4. . Because of the challenges of giving this therapy—including cell acquisition in very ill patients and complicated management of cytokine release syndrome—only 32 designated centers in the U.S. will be initially approved to administer Kymriah. 2012; 7(12):e52655. “I am the physician in charge of the pediatric cancer and blood diseases program at Children’s Hospital Los Angeles (CHLA) and the University of Southern California. Biol Blood Marrow Transplant. View in PubMed, Disease detection methodologies in relapsed B-cell acute lymphoblastic leukemia: Opportunities for improvement Pediatr Blood Cancer. View in PubMed, Nucleoside analogues in the therapy of Langerhans cell histiocytosis: a survey of members of the histiocyte society and review of the literature Med Pediatr Oncol. 2002; 4(6):539-49. . View in PubMed, Anti-CD22 immunotoxin RFB4(dsFv)-PE38 (BL22) for CD22-positive hematologic malignancies of childhood: preclinical studies and phase I clinical trial Clin Cancer Res. View in PubMed, Monoclonal antibody-based therapies: a new dawn in the treatment of acute lymphoblastic leukemia J Clin Oncol. Alan Wayne Metcalf #103334. View in PubMed, Protein Kinase Inhibitor H89 Enhances the Activity of Pseudomonas Exotoxin A-Based Immunotoxins . 1999 Nov; 33(5):476-81. . 2012 Jul 12; 120(2):244-6. . This is a past event. That figure grew even higher Tuesday night (Oct. 2) at its annual Spirit of Excellence dinner in Los Angeles View in PubMed, Bone marrow homing and engraftment of human hematopoietic stem and progenitor cells is mediated by a polarized membrane domain Blood. 2012 May; 18(5):698-707. . 2009 Dec; 41(3):209-16. . 2020 05; 67(5):e28112. View in PubMed, Collaborative multicenter investigation of marrow transplantation for sickle cell disease: current results and future directions Biol Blood Marrow Transplant. T.J. Martell Foundation has raised more than $280 million for cancer research. View in PubMed, Immune-based therapeutics for pediatric cancer Expert Opin Biol Ther. The U.S. Food and Drug Administration recently approved a novel cancer treatment that resulted in patients with resistant leukemia going into remission, and the majority remaining cancer free after a year. View in PubMed, Investigating the biology of relapsed acute leukemia: Proceedings of the Therapeutic Advances for Childhood Leukemia & Lymphoma (TACL) Consortium Biology Working Group Pediatr Hematol Oncol. 2014 Jan; 20(1):4-13. . The Team: $156,565 TOTAL RAISED SO FAR David Abbott. The approach is called CAR-T therapy, and it uses a patient’s own white blood cells that have been genetically re-engineered to specifically target and kill cancer cells. Lancet Haematol. . 2010 Feb; 57(1):1-25. . 2010 Feb; 22(1):2-11. . 2016 12; 22(12):2149-2154. . 2018 09; 65(9):e27265. Get appointment information and hours of operation for Alan Wayne, practicing Hematology/Oncology doctor in Los Angeles, CA. View in PubMed, Integrin a6 mediates the drug resistance of acute lymphoblastic B-cell leukemia Blood. View in PubMed, Impact of bone marrow transplantation for symptomatic sickle cell disease: an interim reportMulticenter investigation of bone marrow transplantation for sickle cell disease. The newly licensed therapy has been approved to treat children and young adults with relapsed acute lymphoblastic leukemia. One each from columns A and B. View in PubMed, Anti-CD22-chimeric antigen receptors targeting B-cell precursor acute lymphoblastic leukemia Blood. 2020 11 18. . View in PubMed, Domain II of Pseudomonas Exotoxin Is Critical for Efficacy of Bolus Doses in a Xenograft Model of Acute Lymphoblastic Leukemia Toxins (Basel). View in PubMed, Pharmacokinetics of intravenous voriconazole in obese patients: implications of CYP2C19 homozygous poor metabolizer genotype Pharmacotherapy. View in PubMed, Clonality in juvenile chronic myelogenous leukemia Blood. Pasadena Magazine's 2016 Top Doctors issue recognizes more than 200 physicians with privileges to practice at Children’s Hospital Los Angeles, a top-r 2004 Feb; 44(2):229-38. . . Alan Wayne is Bruce Wayne's great-great-grandfather and first born generation in Gotham. Director, Graduate Medical Education & Designated Institutional Official, Children's Hospital Los Angeles Attending Physician; Hematology, Oncology and Blood and Marrow Transplantation Professor of Clinical Pediatrics (Educational Scholar) 2018 11; 32(11):2316-2325. . 2014 Oct; 49(10):1259-65. . View in PubMed, NCI First International Workshop on the Biology, Prevention, and Treatment of Relapse after Allogeneic Hematopoietic Stem Cell Transplantation: Report from the Committee on Treatment of Relapse after Allogeneic Hematopoietic Stem Cell Transplantation Biol Blood Marrow Transplant. Bone Marrow Transplant. is the Associate Director for Pediatric Oncology at the USC Norris Comprehensive Cancer Center, Professor of Pediatrics at the Keck School of Medicine of USC, the Director of the Children's Center for Cancer & Blood Diseases at CHLA, the Head of the Division of Hematology, Oncology and Blood & Marrow Transplantation in the Department of Pediatrics, and the Director of the Pediatric … 2000 Mar 15; 95(6):1918-24. . . 2015 Feb 07; 385(9967):517-528. . Biol Blood Marrow Transplant. 2012 Feb; 12(1):20-5. . View in PubMed, Lymphocytic interstitial pneumonitis, elevated IgM concentration, and hepatosplenomegaly in ataxia-telangiectasia J Pediatr. Read more. 2014 Jul; 20(7):1033-9. . Team overview for Leukemia and Lymphoma Program. View in PubMed, Children as hematopoietic cell donors in research: when is it approvable? 2007 Jan; 21(1):169-74. . View in PubMed, Activating signals dominate inhibitory signals in CD137L/IL-15 activated natural killer cells J Immunother. For more information, please contact our New Referrals Office. 2012 Mar; 129(3):762-769. e1. 2015 Mar; 2(3):e87-8.. View in PubMed, T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial Lancet. 4650 W Sunset Blvd. 1949 Nov; 9(11):681-3. . Alan S Wayne's 227 research works with 5,499 citations and 10,279 reads, including: 1-s2.0-S1470204519307296-mmc1.pdf View in PubMed, Phase 1 study of the anti-CD22 immunotoxin moxetumomab pasudotox for childhood acute lymphoblastic leukemia Blood. View in PubMed, Reduced-intensity allogeneic stem cell transplantation in children and young adults with ultrahigh-risk pediatric sarcomas Biol Blood Marrow Transplant. View in PubMed, The PI3Kd Inhibitor Idelalisib Inhibits Homing in an in Vitro and in Vivo Model of B ALL Cancers (Basel). new therapy. View in PubMed, 5-Azacytidine prevents relapse and produces long-term complete remissions in leukemia xenografts treated with Moxetumomab pasudotox Proc Natl Acad Sci U S A. View in PubMed, A validated pediatric disease risk index for allogeneic hematopoietic cell transplantation Blood. A study version is represented by a row in the table. View in PubMed, Bortezomib, Dexamethasone, Mitoxantrone, and Vinorelbine (BDMV): An Active Reinduction Regimen for Children With Relapsed Acute Lymphoblastic Leukemia and Asparaginase Intolerance J Pediatr Hematol Oncol. 2010 Nov; 95(11):1873-9. . 2017; 6(1):1400370. . Claim your profile ... Childrens Hospital Los Angeles. 2010 Aug; 150(3):352-8. . Existing Patients or Family Members: 323-361-4624, New Patients, Referrals and 2nd Opinions: 323-361-4100, About Our Hospital View in PubMed, Proceedings from the National Cancer Institute's Second International Workshop on the Biology, Prevention, and Treatment of Relapse after Hematopoietic Stem Cell Transplantation: introduction Biol Blood Marrow Transplant. Get … 2000 Oct 01; 96(7):2369-72. . . 2013 Nov; 19(11):1534-6. . The opposite of a “one size fits all” strategy, this treatment is individually created for each patient using his or her own cells. 2008 Apr 30; 71(1):61-70. . View in PubMed, Proceedings from the National Cancer Institute's Second International Workshop on the Biology, Prevention, and Treatment of Relapse After Hematopoietic Stem Cell Transplantation: part IIIPrevention and treatment of relapse after allogeneic transplantation. Make an Appointment 2018 Feb; 65(2). View in PubMed, Bexarotene is active against subcutaneous panniculitis-like T-cell lymphoma in adult and pediatric populations Clin Lymphoma Myeloma Leuk. View in PubMed, Financial analysis of chronic transfusion for stroke prevention in sickle cell disease Blood. View in PubMed, Sibling stem cell donor experiences at a single institution Psychooncology. View in PubMed, Outcome of children with multiply relapsed B-cell acute lymphoblastic leukemia: a therapeutic advances in childhood leukemia & lymphoma study Leukemia. Ninety percent of children diagnosed with acute lymphoblastic leukemia are cured. View in PubMed, National Cancer Institute's First International Workshop on the Biology, Prevention, and Treatment of Relapse after Allogeneic Hematopoietic Stem Cell Transplantation: summary and recommendations from the organizing committee Biol Blood Marrow Transplant. Before leading the Institute at Children’s Hospital Los Angeles, he served for 14 years as clinical directors of the Pediatric Oncology Branch of the National Cancer Institute (NCI) at the National Institutes of Health (NIH). Choose either the "Merged" or "Side-by-Side" comparison format to specify how the two study versions are to be displayed. 2013 Nov; 15(11):1406-15. . 2017 10 05; 130(14):1620-1627. . 1995 Jan 01; 85(1):21-30. . WordPress Download Manager - Best Download Management Plugin, Professor of Pediatrics (Clinical Scholar). Alan S Wayne Relapse of cancer remains one of the primary causes of treatment failure and mortality after allogeneic hematopoietic stem cell transplantation (HSCT). View in PubMed, Hematopoietic stem cell transplantation for leukemia Pediatr Clin North Am. 2010 Nov; 24(11):1859-66. . View in PubMed, Blastic plasmacytoid dendritic cell neoplasm in children: diagnostic features and clinical implications Haematologica. Biol Blood Marrow Transplant. 2016 Feb; 34(1):61-5. . Biol Blood Marrow Transplant. View in PubMed, Extracellular vesicles derived from natural killer cells use multiple cytotoxic proteins and killing mechanisms to target cancer cells J Extracell Vesicles. 2010 Nov; 16(11):1467-503. . 2008 Sep 17; 100(18):1271-3. . TACL develops phase I /II clinical trials of new therapies and novel therapy combinations in recurrent childhood leukemia and lymphoma. 2007; 25(1):45-66. . View in PubMed, Pretransplant MRD: the light is yellow, not red Blood. CHLA - Chimeric Antigen Receptor T-cell (CAR-T) Therapy The Cell Therapy Program at CHLA is led by Michael Pulsipher, MD and Alan Wayne, MD both of whom have significant expertise in CAR T-cell therapy and other cutting-edge immunotherapeutic and cell therapy approaches, having treated many patients. Product performance in haematological malignancies before and after marketing authorisation Lancet Oncol doctor immediately referred him to chla in. 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